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Retrieved June 8, 2025, from Santen, R

Discard any opened bacteriostatic water vial after the manufacturers in-use period (commonly 28 days) regardless of remaining volume

Clinical Evidence Supporting Glutathione in Cosmetic Dermatology A number of peer-reviewed studies support the efficacy of glutathione in improving skin tone and overall skin quality: 2012 Randomized Controlled Trial (Thailand) Participants who received oral glutathione for 4 weeks showed statistically significant reductions in melanin index across multiple anatomical sites, demonstrating visible skin-lightening outcomes

TB500 has been evaluated at 28 mg/week in certain animal research protocols

Directions for Use: Apply a small amount evenly to clean, dry face at night